Jurnal Farmasi Indonesia

Potency Lotion Pandanus Leaf Extract (Pandanus amaryllifolius Roxb.) As Repellent Mosquito Culex Sp

Farida Mutik Istikomah — 2024-05-31

Pandan wangi leaves contain flavonoids and have repellent activity. This study uses fragrant pandanus leaves as a substitute for DEET chemicals as repellent for Culex sp Pandan wangi leaves formulated in lotion with concentrations of 4, 8, and 12%. The physical quality of the lotion was observed organoleptically, as well as homogeneity, viscosity, pH, spreadability, stickiness, emulsion type, and cycling test. The test method for repellent effectivity is inserting a proband hand in a cage containing 50 mosquitoes and observing mosquitoes sticking for 5 minutes every hour with a total observation of 6 hours. The results of the repellent effectiveness test and physical quality test on the lotion formulation obtained with a concentration of 4,8 and12% have not shown effective potential results because it still has a repulsion of<80%, the highest protection power result is obtained from the concentration of 12% extract which has a repulsive power of 54.47% the more significant the concentration of the added extract, the greater the protection power produced, But all formulas used have good quality tests.

Study of Drug Related Problems in Type 2 Diabetes Patients with Covid-19

Pande Made Desy Ratnasari — 2024-05-31

Type 2 Diabetes Mellitus (T2DM) is one of several factors exacerbating Covid-19. Previous studies showed that polypharmacy might lead to Drug Related Problems (DRPs) due to some drugs administered during the management of both conditions. This study aimed to analyze DRPs in T2DM patients with Covid-19 at a private hospital in Denpasar, Bali.

This study was designed as cross-sectional research in June-July 2022. Data was collected from patient medical records based on inclusion and exclusion criteria. The inclusion criteria were patients T2DM with Covid-19, aged ³18 years, hospitalized between July 2020-July 2021, received Covid-19 and antidiabetic therapy. Patients who transferred to other hospitals during treatment were excluded. The DRPs included 6 aspects, namely indications without therapy, therapy without indications, inappropriate drugs, insufficient drug doses, high drug doses, and drug interactions which were analyzed by reffering to therapeutic guidelines.

Majority of 106 respondents is male (66.98%), aged 46-65 years (70.75%), had a fever (30.72%), oxygen saturation 91-95% (55.66%), blood glucose 228.38 mg/dL, temperature 36.68°C, degree of high severity (49.06%), length of stay ≥10 days (52.83%), and final status as discharge (80.19%). Patients received an average of 10.89±3.46 number of drugs. The highest number of antidiabetic use was rapid-acting insulin group (38.97%) then insulin aspart (20.00%). A number of 86.00% of the prescribed patients had experienced at least 1 type of DRPs (61.54%). The top three DRPs events found in this study were drug interactions (87,75%), inappropriate drugs (7,28%), and therapy without indications (4,97%). Role of pharmacists is required for preventing and minimizing DRPs events in the practice.

Study of Drug Interactions in Typhoid Fever Patients at X Hospital in Surakarta

Eersta Zusvita Widyastuti — 2024-05-31

Salmonella typhi bacteria reside in the human body and cause an infection known as typhoid fever. The number of cases of typhoid fever in Indonesia reaches 81% per 100,000 people. The use of various drugs in the treatment of typhoid fever will increase the possibility of drug interactions.

This research is a descriptive observational cross-sectional study. Data from medical records of typhoid fever patients at "X" Hospital in Surakarta from January to December 2021 were used in this study. Potential drug interactions were analyzed using the Drug Interaction Checker application and Stockley's Drug Interaction Guidebook. The data were then statistically analyzed using SPSS 25.

The results showed that out of 96 patients with typhoid fever, 29 experienced potential drug interactions. Of the 29 patients, 68 cases occurred, consisting of 41 non-antibiotic-non-antibiotic cases (60.3%) and 27 antibiotic-non-antibiotic cases (39.7%). The highest potential drug interactions were levofloxacin and ondasetron in 8 cases, dexamethasone-omeprazole in 7 cases, ceftriaxone-lansoprazole in 5 cases and sucralfate-lansoprazole in 5 cases. Based on the level of severity, the potential drug interactions that are minor are 26 cases (38.235%), moderate drug interactions are 26 cases (38.235%) and major interactions are 16 cases (23.53%). Based on the mechanism, the most potential drug interactions in pharmacokinetics occurred, namely 52 cases (72.47%) compared to pharmacodynamics as many as 16 cases (23.53%).

The Relationship Between Knowledge and The Use of Health Supplements During The Pandemic Towards Non-Medical Students of Sanata Dharma University

Yosef Wijoyo — 2024-05-31

The World Health Organization (WHO) declared COVID-19 as a pandemic on 11 March 2020. Based on the data on the distribution of the development of Covid-19, the pandemic in Indonesia itself is still high. One of the efforts to prevent the spread of COVID-19 cases is by increasing the body's immune system. Consuming health supplements is one of the efforts to increase endurance because it has the function to maintain, improving and/or repairing health. This study aims to determine whether there is a relationship between knowledge and actions to use health supplements among non-health students at Sanata Dharma University.

This study is a type of Analytical Observational research with a cross-sectional approach. The research instrument is a questionnaire that was distributed online through the Google Form platform. The sample in this study was 368 respondents. The Data analysis in this study uses descriptive statistical tests, normality tests, chi-square tests and simple linear regression tests.

In respondents' knowledge of health supplements, 85.9% of 316 respondents fell into the "GOOD" category, and 14.1% of 52 respondents fell into the "BAD" category. While the respondents that use health supplements is 42.4% of 156 respondents, 34.5% of 127 respondents fall into the category of "GOOD", and 23.1% of 85 respondents fall into the category of "GOOD" and there are no respondents who fall into the category of "BAD" and "VERY BAD". This study concludes that there is a relationship between knowledge and actions to use health supplements during a pandemic among non-health students at Sanata Dharma University Yogyakarta, with a strength level, namely "STRONG" with a correlation coefficient value of 0.610

Overview of The Level of Quality of Life at A Productive Age with Overweight Using Pharmacological and Non-Pharmacological Therapies in Palu City

Muhamad Rinaldhi Tandah, Mr. — 2024-05-31

Quality of life is a self-view of an individual in the aspect of assessing one's life. Being overweight to obese of productive age is a factor that can influence the level of assessment of the quality of life. The purpose of this study was to determine the picture of the level of quality of life at a productive age with overweight using pharmacological and non-pharmacological therapies, and to find out whether there was a significant difference between the level of quality of life and overweight using pharmacological and non-pharmacological therapies.
This study used a non-experimental method that is descriptive with cross-sectional data collection. Respondent data will be retrieved using a questionnaire (WHOQOL-BREF) and will be analyzed using t-test. The determination of samples in this study using the Yamane and Isaac formulas from a total population of 649 people obtained a sample of 155 respondents.
The results of this study can interpret from the data of respondents who use pharmacological therapy, the highest average score is found in the psychological with a value of 71.65, where these results in general in the good category. The highest average score with non-pharmacological therapy is 75.7 with a good category. The significance value obtained from the Independent sample t-test was 0.75 which can interpret that this data did not have a significant difference, due to factors of therapy consumed by respondents by combining pharmacological therapy with the use of other medicines such as herbal medicine or traditional medicine, and supported by a poor lifestyle.