Gambaran  Kejadian Efek Samping Obat Antibiotik Golongan Sefalosporin Pada Pasien Rawat Inap di Rumah Sakit “X” Surakarta Periode 2024

Brianne Corina; Yane Dila Keswara; Francisca Tri Wituningtyas

doi:10.31001/jfi.v22i1.2724

Abstract

In the use of cephalosporin antibiotics, it is necessary to be aware of the side effects on patients. One of the effects of drug side effects on patients is the emergence of new diseases. This study is a descriptive observational study with data collection using a retrospective method to determine the description of the occurrence of side effects of cephalosporin antibiotic drugs. The results of this study were 15 patients who experienced side effects of the drug consisting of 6 male patients (40%) and 9 female patients (60%). Ceftriaxone is the drug that most often causes side effects (33.33%). The most common form of manifestation is shortness of breath accompanied by swelling and itching (26.67%). The end of the side effects of the drug is cured (93.33%). Inj Dexamethasone 5 mg (iv) and inj Diphenhydramine 10 mg (iv) (33.33%) are drugs that are often used to overcome side effects. The highest naranjo score results are on a scale of 7 or probable (60%). These results indicate that the use of cephalosporin antibiotics can cause side effects of the drug.

References

[1] Permenkes, 2016. Peraturan Menteri Kesehatan Republik Indonesia Nomor 72 Tahun 2016 Tentang Standar Pelayanan Kefarmasian di Rumah Sakit. Jakarta:Kementrian Kesehatan Republik Indonesia
[2] Balai Pengawasan Obat dan Makanan Pepublik Indonesia. 2012. Pedoman Monitoring Efek Samping Obat (MESO) Bagi Tenaga Kesehatan. Jakarta: BPOM RI.
[3] Handayani, D. S., Rusli, R., & Ibrahim, A, “Analisis Karakteristik dan Kejadian Drug Related Problems Pada Pasien Hipertensi di Puskesmas Temindung Samarinda”, Jurnal Sains dan Kesehatan., vol. 1, no. 2, pp. 75-81, 2015. [Online]. Available: https://jsk.ff.unmul.ac.id/index.php/JSK/article/view/33
[4] Hardiana, I., Panduwiguna, I., Abdaul Mujaki, A, “Evaluasi efek samping obat pada pasien rawat inap di Rumah Sakit “X” di Jakarta,” Health Sciences and Pharmacy Journal., vol. 6, no. 1, pp. 35-41, 2022. doi : 10.32504/hspj.v%vi%i.67
[5] Permenkes,2021. Peraturan Menteri Kesehatan Republik Indonesia Nomor 28 Tahun 2021 Tentang Pedoman Penggunaan Antibiotik. Jakarta: Kementerian Kesehatan Republik Indonesia.
[6] Devansh, M., and Kumar, “Cephalosporins: A Review on Imperative Class of Antibiotics,” Inventi Rapid: Molecular Pharmacology., vol. 2016, no. 1, pp. 1-6.
[7] BPOM RI., 2021. Buletin Berita MESO Volume 39. Edisi 1. Jakarta: Pusat Farmakovigilans/MESO Nasional.
[8] M. K. Mudigubba, Y. Rajashekarachari, and S. Dahiya, “Evaluation of Predisposing Factors Associated with Suspected Adverse Drug Reactions of Hospitalized Patients,” Journal of Young Pharmacists, vol. 10, no. 2, pp. 202–207,2018, doi: 10.5530/jyp.2018.10.45.
[9] S. Watson, O. Caster, P. A. Rochon, and H. den Ruijter, “Reported adverse drug reactions in women and men: Aggregated evidence from globally collected individual case reports during half a century,” EClinicalMedicine, vol. 17, Dec. 2019, doi: 10.1016/j.eclinm.2019.10.001.
[10] J. B. Schwartz, “The Influence of Sex on Pharmacokinetics,” Clinical Pharmacokinetics, Vol. 42, No. 2, 2003, pp. 107-121. doi:10.2165/00003088-200342020-00001.
[11]L. Efriani, Annisa, S. Jatiningsih, and D. A. Perwitasari, “Pengaruh Karakteristik Pasien terhadap Adverse Drug Reactions di RSUD Dr. M. Yunus Bengkulu,” Jurnal Permata Indonesia, vol. 10, no.2 pp. 23, 2019 doi: https://doi.org/10.59737/jpi.v10i2.77.
[12]Jannah M, Sari OY, Almasdy D. “Kajian Kejadian Efek Samping Obat (ESO) Pada Pasien Geriatri di Ruangan Rawat Inap Interne Sebuah Rumah Sakit Swasta di Kota Bukittinggi Sumatera Barat”. Jurnal Farmasi, vol.6, no.2, pp,178-185, 2014, doi:https://doi.org/10.35451/jfm.v6i2.2142.
[13] Bone, N. R., & Usiono, U. “Systematic Literature Review: Efek Samping Obat Pada Kesehatan Tubuh”. Jurnal Pendidikan Tambusai, vol.7 , no.3, pp,31030–31034, 2023. doi : https://doi.org/10.31004/jptam.v7i3.12052.
[14] Jerry. “ Evaluasi Kejadian Efek Samping Obat Antibiotika Pada Pasien Rawat Inap Rumah Sakit “X” Jakarta, Indonesia”. Social Clinical Pharmacy Indonesia Journal,vol.2, no.1, pp.69-74,2017 doi: https://doi.org/10.52447/scpij.v2i1.903.
[15] Sánchez-Borges M, Asero R, Ansotegui IJ, Baiardini I, Bernstein JA, Canonica GW, et al. Diagnosis and treatment of urticaria and angioedema: A worldwide perspective. World Allergy Organ J,vol.5, no.11,pp. 125-147 ,2012
[16]Kemenkes, 2024. Penyakit Kulit Akibat Reaksi Simpang Obat. Jakarta: Kementerian Kesehatan Republik Indonesia 2024.
[17]Holdcroft A, Jaggar S, penyunting. Core topics in pain. New York: Cambridge University Press; 2005. hlm. 161–70
[18]National Center for Biotechnology Information. PubChem Compound Summary for CID3100,Diphenhydramine.https://pubchem.ncbi.nlm.nih.gov/compound/Diphenhydramine.