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Abstract
Green tea leaves contain secondary metabolites of the flavonoid group (catechins), alkaloids, saponins, steroids, and tannins which have an antibacterial activity that causes acne. Anti-acne from green tea leaf ethanol extract was developed in serum preparations to facilitate topical use. This study aims to determine the effect of varying concentrations of xanthan gum on physical quality, stability, and antibacterial activity and determine which formula has good physical quality and stability and can inhibit P. acnes bacteria effectively.
Green tea leaves were extracted by the maceration method using 96% ethanol formulated into three formulas with 8% green tea leaf extract concentration and variation of xanthan gum concentration, respectively 1; 1,2; and 1.4%. The serum preparations were tested for organoleptic, homogeneity, pH, viscosity, dispersibility, adhesion, and stability, then continued with the antibacterial activity test was continued using the hole method. The data were then subjected to a statistical analysis test using the SPSS program.
The results showed that serum preparations of green tea leaf extract concentration of 8% with 1% and 1.2% variations of xanthan gum concentrations had good physical quality and stability. The inhibition power of serum preparations against P. acnes bacteria in F1 is 15.42 mm, F2 is 15.31 mm, F3 is 13.97 mm, and K(-) is 2.57 mm. The results also showed that formula 1 with a 1% concentration of xanthan gum in the serum had the best physical quality and stability and effectively inhibited P. acnes bacteria.
keywords: Propionibacterium acnes, Camellia sinensis L., serum, xanthan gum