Study of Drug Interactions in Typhoid Fever Patients at X Hospital in Surakarta

  • Eersta Zusvita Widyastuti Universitas Kusuma Husada
  • Adhi Wardhana Amrullah Universitas Kusuma Husada
  • Agnes Prawistya Sari Universitas Kusuma Husada
  • Avianti Eka Dewi Aditya Purwaningsih Setia Budi Surakarta
DOI: https://doi.org/10.31001/jfi.v21i1.2140

Abstract

Salmonella typhi bacteria reside in the human body and cause an infection known as typhoid fever. The number of cases of typhoid fever in Indonesia reaches 81% per 100,000 people. The use of various drugs in the treatment of typhoid fever will increase the possibility of drug interactions.

This research is a descriptive observational cross-sectional study. Data from medical records of typhoid fever patients at "X" Hospital in Surakarta from January to December 2021 were used in this study. Potential drug interactions were analyzed using the Drug Interaction Checker application and Stockley's Drug Interaction Guidebook. The data were then statistically analyzed using SPSS 25.

The results showed that out of 96 patients with typhoid fever, 29 experienced potential drug interactions. Of the 29 patients, 68 cases occurred, consisting of 41 non-antibiotic-non-antibiotic cases (60.3%) and 27 antibiotic-non-antibiotic cases (39.7%). The highest potential drug interactions were levofloxacin and ondasetron in 8 cases, dexamethasone-omeprazole in 7 cases, ceftriaxone-lansoprazole in 5 cases and sucralfate-lansoprazole in 5 cases. Based on the level of severity, the potential drug interactions that are minor are 26 cases (38.235%), moderate drug interactions are 26 cases (38.235%) and major interactions are 16 cases (23.53%).  Based on the mechanism, the most potential drug interactions in pharmacokinetics occurred, namely 52 cases (72.47%) compared to pharmacodynamics as many as 16 cases (23.53%).

Keywords: Typhoid Fever; Potential Drug Interaction; Mechanism of Drug Interaction; Severity of Drug Interaction, typhoid fever, drug interaction, potency, severity

References

1. Bhan MK, Bahl R, Bhatnagar S. Typhoid and paratyphoid fever. Lancet [Internet]. 2005 Aug 27 [cited 2023 Aug 7];366(9487):749–62. Available from: https://pubmed.ncbi.nlm.nih.gov/16125594/
2. Saputra DA. Terapi pada Demam Tifoid Tanpa Komplikasi. Jurnal Penelitian Perawat Profesional [Internet]. 2021 Feb 28 [cited 2023 Aug 7];3(1):213–22. Available from: https://jurnal.globalhealthsciencegroup.com/index.php/JPPP/article/view/392
3. Kementerian Kesehatan RI. SISTEMATIKA PEDOMAN PENGENDALIAN PENYAKIT DEMAM TIFOID. 1st ed. Jakarta: Kementerian Kesehatan RI; 2013. 1–62 p.
4. Gede Krisna Yoga Pratama I, Wiradewi Lestari A. EFEKTIFITAS TUBEX SEBAGAI METODE DIAGNOSIS CEPAT DEMAM TIFOID. Intisari Sains Medis [Internet]. 2015 Apr 15 [cited 2023 Aug 7];2(1):70–3. Available from: https://isainsmedis.id/index.php/ism/article/view/87
5. Naveed A, Journal ZAES, 2016 undefined. Treatment of typhoid fever in children: comparison of efficacy of ciprofloxacin with ceftriaxone. core.ac.ukA Naveed, Z AhmedEuropean Scientific Journal, 2016•core.ac.uk [Internet]. 2016 [cited 2023 Aug 7];12(6):1857–7881. Available from: https://core.ac.uk/download/pdf/328025356.pdf
6. Patel PS, Rana DA, Suthar J V., Malhotra SD, Patel VJ. A study of potential adverse drug-drug interactions among prescribed drugs in medicine outpatient department of a tertiary care teaching hospital. J Basic Clin Pharm [Internet]. 2014 [cited 2023 Aug 7];5(2):44. Available from: /pmc/articles/PMC4074695/
7. Tandi J. KAJIAN KERASIONALAN PENGGUNAAN OBAT PADA KASUS DEMAM TIFOID DI INSTALASI RAWAT INAP ANUTAPURA PALU. PHARMACON: Jurnal Ilmiah Farmasi [Internet]. 2017 Oct 10 [cited 2023 Aug 7];6(4):184–91. Available from: https://ejournal.unsrat.ac.id/v3/index.php/pharmacon/article/view/17749
8. Sulistiati PT, Hakim AR, Azizah T. POTENTIAL DRUG INTERACTION AT TYPHOID FEVER IN-PATIENT OF REGIONAL HOSPITAL “X” ALONG THE YEAR OF 2011 [Skripsi]. [Surakarta]: Universitas Muhammadiyah Surakarta; 2013.
9. Pertiwi G, Niruri R, Tanasale J, Erlangga I. Potensi Interaksi Obat pada Penggunaan Antibiotika Golongan Fluorokuinolon dari Pasien Dewasa dengan Demam Tifoid. Jurnal Farmasi Udayana [Internet]. 2014 [cited 2023 Aug 7];3(2):17–21. Available from: https://ojs.unud.ac.id/index.php/jfu/article/download/12046/8366
10. Khairunnisa S, Hidayat EM, Herardi R. Hubungan Jumlah Leukosit dan Persentase Limfosit terhadap Tingkat Demam pada Pasien Anak dengan Demam Tifoid di RSUD Budhi Asih Tahun 2018–Oktober 2019. Prosiding Seminar Nasional Riset Kedokteran (SENSORIK) [Internet]. 2020 [cited 2023 Aug 7];1(1):60–9. Available from: https://conference.upnvj.ac.id/index.php/sensorik/article/view/434
11. Kementerian Kesehatan RI. Peraturan Menteri Kesehatan No 25 Tahun 2014 tentang Upaya Kesehatan Anak. 25 Indonesia; 2014 p. 1–84.
12. Nainggolan R. KARAKTERISTIK PENDERITA DEMAM TIFOID RAWAT INAP DI RUMAH SAKIT TENTARA TK-IV 01.07.01 PEMATANGSIANTAR TAHUN 2008 [Skripsi]. [Medan]: Universitas Sumatera Utara; 2009.
13. Dasopang E, Harahap U, Lindarto D. Polifarmasi dan interaksi obat pasien usia lanjut rawat jalan dengan penyakit metabolik. Jurnal Farmasi Klinik Indonesia [Internet]. 2015 Dec [cited 2023 Aug 7];4(4):235–41. Available from: http://jurnal.unpad.ac.id/ijcp/article/view/12976
14. Eldafira E. Studi Pola dan Penyebab Long QT Syndrome. Majalah Pratista Patologi [Internet]. 2023 Jan 1 [cited 2023 Aug 7];8(1):1–4. Available from: http://www.majalahpratistapatologi.com/p/index.php/journal/article/view/110
15. Yuliawati Y, Savira RD, Sardiana E. Analisis Potensi Interaksi Obat Pasien Geriatri di Bangsal Penyakit Dalam Salah Satu Rumah Sakit di Jambi. Indonesian Journal of Pharma Science [Internet]. 2021 Jul 1 [cited 2023 Aug 7];3(1). Available from: https://repository.unja.ac.id/36274/
16. Bailie GR, Johnson CA, Mason NA, St Peter WL. MEDFACTS POCKET GUIDE OF DRUG INTERACTIONS. 2nd ed. NephrologyPharmacy Associates; 2004. 1–69 p.
17. Barliana MI, Sari DR, Faturrahman M. Analisis Potensi Interaksi Obat dan Manifestasi Klinik Resep Anak di Apotek Bandung. Indonesian Journal of Clinical Pharmacy [Internet]. 2013 Oct 2 [cited 2023 Aug 7];2(3):121–6. Available from: https://jurnal.unpad.ac.id/ijcp/article/view/12765
18. Urzúa N, Messina MJ, Caverzan M, Prieto G, Lüders C, Errecalde C. Pharmacokinetics of levofloxacin after single intravenous and oral administration, and its interaction with sucralfate in mixed-breed dogs. Xenobiotica. 2020;1490–3.
19. Baxter K. Stockley’s Drug Interactions. 9th ed. Baxter K, editor. London: Pharmaceutical Press; 2010. 1–1791 p.
20. Chelkeba L, Alemseged F, Bedada W. Assessment of potential drug-drug interactions among outpatients receiving cardiovascular medications at Jimma University specialized hospital, South West. Int J Basic Clin Pharmacol [Internet]. 2013 [cited 2023 Aug 7];2(2):144–52. Available from: https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=f4819cbe792b7016673be1dba2434ecf5e73b504
Published
2024-05-31
Issue
Vol 21 No 1 (2024): Jurnal Farmasi Indonesia
Section
Articles