The Activity of Kemuning Leaves Extract (Murraya paniculata (L.) Jack) as Hepatoprotector of Rats Exposed By Cigarette Smoke

Abstract

Cigarettes is a source of free radicals that can cause oxidative stress. It can cause
functional failure of vital organs in the body including the liver that indicated by SGPT and
SGOT increment. This research was aimed to observe the activity of 70% ethanol extract of
kemuning leaves (Murraya paniculata (L.) Jack) on SGPT and SGOT digression of male white
rats exposed by cigarette smoke.
This research was performed using 25 rats that were divided into 5 groups: normal
control (Ko), negative control (Kn), and 3 treatment groups that were given 70% ethanol extract
of kemuning leaves with 100 mg / KgBW (K1), 200 mg / KgBW (K2), and 400 mg / KgBW
(K3).The SGPT and SGOT levels were analyzed by one-way ANOVA and Tukey test.
One-way ANOVA results showed there was a treatment effect on controls (p <0.05).
The results of the Tukey showed that the SGPT levels in doses II and III were significantly
different from the negative controls but did not differ significantly from the normal controls with
level value of 34.6 U / L (dose II) and 14.4 U / L (dose III) . At SGOT levels all treatment groups
showed significantly different comparing to negative controls and not significantly different to
normal controls with level value of 193.6 U / L (dose I), 191.4 U / L (dose II), 156.6 U / L L (dose
III). It can be concluded that 70% ethanol extract of kemuning leaves has activity as a
hepatoprotector