Synthesis of 2,4-Dihydroxyacetophenone Compound and its Antioxidant Activity Assay

Abstract

Antioxidant is very important to keep human’s health because of its capability to reduce free
radical. Acetophenone and its derivates are reported as potential antioxidant. The aim of this
research was to find antioxidant activity of 2,4-dihydroxyacetophenone compound synthesized
from resorcinol.
The research was performed by synthesizing 2,4-dihydroxyacetophenon through Friedel-
Crafts acylation from resorsinol. The structure of the compound was elucidated using gas
chromatography, mass spectrometer, infrared spectrophotometer, and antioxidant test was
using DPPH method.
The results showed that product was succesfully synthesized. Yellowish-orange solid was
obtained from synthesis with 86,14% of yield and confirmed as 2,4-dihydroxyacetophenone.
The product showed weak antioxidant activity with 36,72 ppm of IC50