Study Of Potential Antibiotics And Other Drugs Interactions On Pneumonia Patients Prescription In Intensive Care Unit
Abstract
Pneumonia is one of the most common acute lower respiratory tract infection that causes morbidity and mortality. Most of it is caused by bacteria. Antibiotics is the main therapy of bacterial infection cases. Concomitant use of antibiotics and other drugs may risk harmful interaction. This study aimed to determine the potential antibiotic drug interactions and their effects on the patient's condition based on clinical data and laboratory.
A retrospective study were conducted in ICU, NICU and PICU. Medical records of pneumonia patients in 2016 who met the inclusion criteria, including patients diagnosed with pneumonia with co-morbidities, received antibiotic therapy at least 3 days, and had bacterial culture data. Drug interactions were analyzed using Stockley's Drug Interaction, Drug Interaction Fact, and Medscape then calculated the percentage potential of interaction, phase, and significance of interactions.
The results showed that among 28 patient there were 17 types of drugs which potentially cause drug interactions in patients with pneumonia based on literature. Percentage of pharmacokinetics drug interaction was 80%; pharmacodynamics was 20%. Potential drug interactions on metabolism phase were 44%; excretion phase was 36%. The potential effect of drug interactions was major (10%), moderate (80%) and minor (10%). Potentially, most of drugs interact in the metabolic phase with moderate significance. The high drug interaction potential was gentamycin and furosemide with moderate significance about 16%.
Keywords:
antibiotics, drug interaction, intensive care unit, pneumonia
References
Dahlan, Z., 2007, Buku Ajar Ilmu Penyakit Dalam Jilid II Edisi IV, Pusat Penerbitan Departemen Ilmu Penyakit Dalam, Universitas Indonesia, Jakarta
Kemenkes RI, 2016, Profil Kesehatan Indonesia 2015, Kementrian Kesehatan RI, Jakarta
Kemenkes RI, 2007, Riset Kesehatan Dasar : Laporan Nasional, Badan Penelitian dan Pengembangan Kesehatan, Kemenkes RI, Jakarta
Kemenkes RI, 2013, Riset Kesehatan Dasar : Laporan Nasional, Badan Penelitian dan Pengembangan Kesehatan, Kemenkes RI, Jakarta
Dinkes, 2015, Profil Kesehatan Kota Madiun Tahun 2014, Dinas Kesehatan Kota Madiun, Madiun
Susanti, E., Utomo, W., dan Dewi, Y.I., 2015, Identifikasi Faktor Resiko Kejadian Infeksi Nosokomial Pneumonia Pada Pasien Yang Terpasang Ventilator Di Ruang Intensive Care, Jurnal Online Mahasiswa, 2(1) : 590-599.
Tjay, T.H., dan Rahardja, K., 2013, Obat-Obat Penting, Edisi VI, PT. Elex Media Komputindo, Jakarta
Katzung, 2014. Farmakologi dasar dan Klinik edisi 12, EGC, Jakarta
Magro,L Moretti, U., Leone ,R., 2012, Epidemiology and characteristics of adverse drug reactions caused by drug-drug interactions, Expert Opin Drug Saf, 11: 83-94 doi: 10.1517/14740338.2012.631910
Erviana, R. 2017,Potensi Interaksi Obat Pada Pasien Terdiagnosa Pneumonia Di Rumah Sakit Paru Respira Yogyakarta, Pharmacy : Jurnal Farmasi Indonesia, 14(2):199-211, doi : 10.30595/pharmacy.v14i2.1989
Farida, Y., Putri, V.W., Hanafi, M., Herdianti,N.S., 2020, Profil Pasien dan Penggunaan Antibiotik pada Kasus Community-Acquired Pneumonia Rawat Inap di Rumah Sakit Akademik Wilayah Sukoharjo , Journal of Pharmaceutical Science and Clinical Research, 2020, 02, 151-164. doi: 10.20961/jpscr.v5i2.39763
Farida, Y. dan Sholekhah, A., 2016, Identification Of Potentialantibiotics – Drugs interaction On Pneumonia Prescription, Journal of Pharmaceutical Science and Clinical Research, 2016, 01(02): 90 – 101. doi: 10.20961/jpscr.v1i2.1940
Jazbar,J., Locatelli I., Horvat, N., Kos,M., 2018, Clinically relevant potential drug–drug interactions among outpatients: A nationwide database study, Research in Social and Administrative Pharmacy,14(6): 572-580 doi: 10.1016/j.sapharm.2017.07.004
Bakker T, Abu-Hanna A, Dongelmans DA, Vermeijden WJ, Bosman RJ, de Lange DW, et al. 2021,Clinically relevant potential drug-drug interactions in intensive care patients: A large retrospective observational multicenter study. J Crit Care, 62:124–30. doi: 10.1016/j.jcrc.2020.11.020
Eida, M.N, El-Maraghy M., Azab N., Khaled (2015) ‘Pattern of hospital-acquired pneumonia in Intensive Care Unit of Suez Canal University Hospital’, Egyptian Journal of Chest Diseases and Tuberculosis. The Egyptian Society of Chest Diseases and Tuberculosis, 64(3): 625–631. doi: 10.1016/j.ejcdt.2015.03.028
Rozenbaum, M. H. Mangen, Marie Josee J. Huijts, Susanne M. van der Werf, Tjip S. Postma, Maarten J, 2015, Incidence, direct costs and duration of hospitalization of patients hospitalized with community-acquired pneumonia: A nationwide retrospective claims database analysis’, Vaccine, 33(28): 3193–3199. doi: 10.1016/j.vaccine.2015.05.001
Monita, O., Yani, F. F., dan Lestari, Y., 2015, Profil Pasien Pneumonia Komunitas di Bagian Anak RSUP Dr. M. Djamil Padang Sumatera Barat, Jurnal Kesehatan, 4(1) : 218-226. doi: 10.25077/jka.v4i1.225
Puspitasari, D.E., dan Syahrul F., 2015, Faktor Risiko Pneumonia Pada Balita Berdasarkan Status Imunisasi Campak dan Status ASI Eksklusif. Jurnal Berkala Epidemiologi,3(1):69-81
Arnata, A., Cahaya, N., dan Intannia, D., 2014, Prevalensi Kejadian Berpotensi Interaksi Obat Pada Pasien Intensive Care Unit (ICU) Di RSUD Ulin Banjarmasin Tahun 2012, Jurnal Pharmascience, 1(1) : 28-34.
Astuti, S.D., dan Endang, E., 2018, Kajian Penggunaan Antihipertensi dan Potensi Interaksi Obat Pada Pengobatan Pasien Hipertensi Dengan Komplikasi, Jurnal Farmasi Indonesia, 15 (2): 148-162. doi:10.31001/jfi.v15i2.483
Syamsudin, 2011, Interaksi Obat Konsep Dasar Dan Klinis, Universitas Indonesia Press, Jakarta.
Pinzone M.R, Cacopardo B., Abbo L., Nunnari G., 2014. Duration of Antimicrobial Therapy in Community Acquired Pneumonia: Less Is More. The Scientific World Journal, 2014, 759138. doi: 10.1155/2014/759138
Rostanti, A., Bawotong, J., dan Onibala, F., 2016, Faktor Faktor yang Berhubungan Dengan Kepatuhan Menjalani Terapi Hemodialisa Pada Penyakit Ginjal Kronik di Ruangan Dahlia dan Melati RSUP Prof. Dr. R. D Kandou Manado, Journal Keperawatan, 4(2):1-6 doi:10.35790/jkp.v4i2.12873
Huldani, 2014, Edem Paru Akut, Karya Ilmiah, Universitas Lambung Mangkurat, Banjarmasin
Prasetya, F., 2006, Evaluasi Penggunaan Antibiotik Berdasarkan Kontraindikasi, Efek Samping dan Interaksi Obat Pada Pasien Rawat Inap dengan Infeksi Saluran Pernapasan Bawah di Rumah Sakit Pati Rapih Yogyakarta Periode Januari-Juni 2005, Thesis, Universitas Gadjah Mada, Yogyakarta.
Baxter, K., 2008, Stockley’s Drug Interaction Eight Edition, Pharmaceutical Press, United States Of America, London.
Medscape, 2017, Drug Interaction Checker, Tersedia di http://reference.medscape.com/drug-interactionchecker, Diakses pada tanggal 6 Juni 2019
Bates, D.E., Beaumont, S.J., and Baylis, B.W., 2002, Ototoxicity Induced by Gentamicin and Furosemide. Annals of Pharmacotherapy. 2002;36(3):446-451. doi:10.1345/aph.1A216
Tatro, S.D., 2008, Drug Interaction Facts, Wolters Kluwer Healths, United Stated of America
Azim, S.A.A., Abdelrahem, M.T., Saud, M.M., and Khattab, A., 2017, Protective Effect Moringa Peregrina Leaves Extract on Acetaminophen-Induced Liver Toxicity in Albino Rats, Africa Journal Tradit Complement Altern Medical, 14(2) : 206-216. doi: 10.21010/ajtcam.v14i2.22
Indiyani, N.S., Susilowati, dan Lestari, S.R., 2015, Pengaruh Pemberian Deksametason Terhadap Kerusakan Hepar Tikus Jantan (Rattus Norvegicus) Galur Wistar, Karya Ilmiah, Universitas Negeri Malang, Malang.
Harjanti, A.T., 2016, Efektivitas Antibiotik Pada Pasien Pneumonia Pediatri di Instalasi Rawat Inap RSUD dr. Moewardi Surakarta Tahun 2014-2015, Tugas Akhir, Universitas Sebelas Maret, Surakarta.
Simarmata, M., 2010, Pharmacist Intervention on Drug Related Problems of Stroke and Cardiovascular Disorders Patients at Intensive Care Unit Dr. Mintohardjo Navy Hospital Jakarta, Thesis, Universitas Indonesia, Depok.
Yulianti, N.R.A., 2016, Identifikasi Drug Related Problems Pada Pasien Congestive Heart Failure Di Instalasi Rawat Inap Rumah Sakit Umum Daerah Panembahan Senopati Bantul Periode Januari Sampai Mei 2015, Karya Tulis Ilmiah, Universitas Muhammadiyah Surakarta, Surakarta.
Saum, L.M., and Balmat, R.P., 2016, Ceftriaxone Potentiates Warfarin Activity Greater Than Other Antibiotics in the Treatment of Urinary Tract Infections, Journal of Pharmacy Practice, 12(2) : 121-124. doi:10.1177/0897190014544798
Manik, U.C., 2012, Studi Retrospektif Interaksi Obat pada Pasien Pediatrik Rawat Inap di RSUP H. Adam Malik Medan Periode Januari-Juni 2012, Skripsi, Universitas Sumatera Utara, Medan.
Bolhuis,M.S., Prashant N. Panday, Arianna D. P, Jos G. W. Kosterink and Alffenaar J.W., 2011, Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactam. Pharmaceutics, 3, 865-913. doi:10.3390/pharmaceutics3040865
Kemenkes RI, 2016, Profil Kesehatan Indonesia 2015, Kementrian Kesehatan RI, Jakarta
Kemenkes RI, 2007, Riset Kesehatan Dasar : Laporan Nasional, Badan Penelitian dan Pengembangan Kesehatan, Kemenkes RI, Jakarta
Kemenkes RI, 2013, Riset Kesehatan Dasar : Laporan Nasional, Badan Penelitian dan Pengembangan Kesehatan, Kemenkes RI, Jakarta
Dinkes, 2015, Profil Kesehatan Kota Madiun Tahun 2014, Dinas Kesehatan Kota Madiun, Madiun
Susanti, E., Utomo, W., dan Dewi, Y.I., 2015, Identifikasi Faktor Resiko Kejadian Infeksi Nosokomial Pneumonia Pada Pasien Yang Terpasang Ventilator Di Ruang Intensive Care, Jurnal Online Mahasiswa, 2(1) : 590-599.
Tjay, T.H., dan Rahardja, K., 2013, Obat-Obat Penting, Edisi VI, PT. Elex Media Komputindo, Jakarta
Katzung, 2014. Farmakologi dasar dan Klinik edisi 12, EGC, Jakarta
Magro,L Moretti, U., Leone ,R., 2012, Epidemiology and characteristics of adverse drug reactions caused by drug-drug interactions, Expert Opin Drug Saf, 11: 83-94 doi: 10.1517/14740338.2012.631910
Erviana, R. 2017,Potensi Interaksi Obat Pada Pasien Terdiagnosa Pneumonia Di Rumah Sakit Paru Respira Yogyakarta, Pharmacy : Jurnal Farmasi Indonesia, 14(2):199-211, doi : 10.30595/pharmacy.v14i2.1989
Farida, Y., Putri, V.W., Hanafi, M., Herdianti,N.S., 2020, Profil Pasien dan Penggunaan Antibiotik pada Kasus Community-Acquired Pneumonia Rawat Inap di Rumah Sakit Akademik Wilayah Sukoharjo , Journal of Pharmaceutical Science and Clinical Research, 2020, 02, 151-164. doi: 10.20961/jpscr.v5i2.39763
Farida, Y. dan Sholekhah, A., 2016, Identification Of Potentialantibiotics – Drugs interaction On Pneumonia Prescription, Journal of Pharmaceutical Science and Clinical Research, 2016, 01(02): 90 – 101. doi: 10.20961/jpscr.v1i2.1940
Jazbar,J., Locatelli I., Horvat, N., Kos,M., 2018, Clinically relevant potential drug–drug interactions among outpatients: A nationwide database study, Research in Social and Administrative Pharmacy,14(6): 572-580 doi: 10.1016/j.sapharm.2017.07.004
Bakker T, Abu-Hanna A, Dongelmans DA, Vermeijden WJ, Bosman RJ, de Lange DW, et al. 2021,Clinically relevant potential drug-drug interactions in intensive care patients: A large retrospective observational multicenter study. J Crit Care, 62:124–30. doi: 10.1016/j.jcrc.2020.11.020
Eida, M.N, El-Maraghy M., Azab N., Khaled (2015) ‘Pattern of hospital-acquired pneumonia in Intensive Care Unit of Suez Canal University Hospital’, Egyptian Journal of Chest Diseases and Tuberculosis. The Egyptian Society of Chest Diseases and Tuberculosis, 64(3): 625–631. doi: 10.1016/j.ejcdt.2015.03.028
Rozenbaum, M. H. Mangen, Marie Josee J. Huijts, Susanne M. van der Werf, Tjip S. Postma, Maarten J, 2015, Incidence, direct costs and duration of hospitalization of patients hospitalized with community-acquired pneumonia: A nationwide retrospective claims database analysis’, Vaccine, 33(28): 3193–3199. doi: 10.1016/j.vaccine.2015.05.001
Monita, O., Yani, F. F., dan Lestari, Y., 2015, Profil Pasien Pneumonia Komunitas di Bagian Anak RSUP Dr. M. Djamil Padang Sumatera Barat, Jurnal Kesehatan, 4(1) : 218-226. doi: 10.25077/jka.v4i1.225
Puspitasari, D.E., dan Syahrul F., 2015, Faktor Risiko Pneumonia Pada Balita Berdasarkan Status Imunisasi Campak dan Status ASI Eksklusif. Jurnal Berkala Epidemiologi,3(1):69-81
Arnata, A., Cahaya, N., dan Intannia, D., 2014, Prevalensi Kejadian Berpotensi Interaksi Obat Pada Pasien Intensive Care Unit (ICU) Di RSUD Ulin Banjarmasin Tahun 2012, Jurnal Pharmascience, 1(1) : 28-34.
Astuti, S.D., dan Endang, E., 2018, Kajian Penggunaan Antihipertensi dan Potensi Interaksi Obat Pada Pengobatan Pasien Hipertensi Dengan Komplikasi, Jurnal Farmasi Indonesia, 15 (2): 148-162. doi:10.31001/jfi.v15i2.483
Syamsudin, 2011, Interaksi Obat Konsep Dasar Dan Klinis, Universitas Indonesia Press, Jakarta.
Pinzone M.R, Cacopardo B., Abbo L., Nunnari G., 2014. Duration of Antimicrobial Therapy in Community Acquired Pneumonia: Less Is More. The Scientific World Journal, 2014, 759138. doi: 10.1155/2014/759138
Rostanti, A., Bawotong, J., dan Onibala, F., 2016, Faktor Faktor yang Berhubungan Dengan Kepatuhan Menjalani Terapi Hemodialisa Pada Penyakit Ginjal Kronik di Ruangan Dahlia dan Melati RSUP Prof. Dr. R. D Kandou Manado, Journal Keperawatan, 4(2):1-6 doi:10.35790/jkp.v4i2.12873
Huldani, 2014, Edem Paru Akut, Karya Ilmiah, Universitas Lambung Mangkurat, Banjarmasin
Prasetya, F., 2006, Evaluasi Penggunaan Antibiotik Berdasarkan Kontraindikasi, Efek Samping dan Interaksi Obat Pada Pasien Rawat Inap dengan Infeksi Saluran Pernapasan Bawah di Rumah Sakit Pati Rapih Yogyakarta Periode Januari-Juni 2005, Thesis, Universitas Gadjah Mada, Yogyakarta.
Baxter, K., 2008, Stockley’s Drug Interaction Eight Edition, Pharmaceutical Press, United States Of America, London.
Medscape, 2017, Drug Interaction Checker, Tersedia di http://reference.medscape.com/drug-interactionchecker, Diakses pada tanggal 6 Juni 2019
Bates, D.E., Beaumont, S.J., and Baylis, B.W., 2002, Ototoxicity Induced by Gentamicin and Furosemide. Annals of Pharmacotherapy. 2002;36(3):446-451. doi:10.1345/aph.1A216
Tatro, S.D., 2008, Drug Interaction Facts, Wolters Kluwer Healths, United Stated of America
Azim, S.A.A., Abdelrahem, M.T., Saud, M.M., and Khattab, A., 2017, Protective Effect Moringa Peregrina Leaves Extract on Acetaminophen-Induced Liver Toxicity in Albino Rats, Africa Journal Tradit Complement Altern Medical, 14(2) : 206-216. doi: 10.21010/ajtcam.v14i2.22
Indiyani, N.S., Susilowati, dan Lestari, S.R., 2015, Pengaruh Pemberian Deksametason Terhadap Kerusakan Hepar Tikus Jantan (Rattus Norvegicus) Galur Wistar, Karya Ilmiah, Universitas Negeri Malang, Malang.
Harjanti, A.T., 2016, Efektivitas Antibiotik Pada Pasien Pneumonia Pediatri di Instalasi Rawat Inap RSUD dr. Moewardi Surakarta Tahun 2014-2015, Tugas Akhir, Universitas Sebelas Maret, Surakarta.
Simarmata, M., 2010, Pharmacist Intervention on Drug Related Problems of Stroke and Cardiovascular Disorders Patients at Intensive Care Unit Dr. Mintohardjo Navy Hospital Jakarta, Thesis, Universitas Indonesia, Depok.
Yulianti, N.R.A., 2016, Identifikasi Drug Related Problems Pada Pasien Congestive Heart Failure Di Instalasi Rawat Inap Rumah Sakit Umum Daerah Panembahan Senopati Bantul Periode Januari Sampai Mei 2015, Karya Tulis Ilmiah, Universitas Muhammadiyah Surakarta, Surakarta.
Saum, L.M., and Balmat, R.P., 2016, Ceftriaxone Potentiates Warfarin Activity Greater Than Other Antibiotics in the Treatment of Urinary Tract Infections, Journal of Pharmacy Practice, 12(2) : 121-124. doi:10.1177/0897190014544798
Manik, U.C., 2012, Studi Retrospektif Interaksi Obat pada Pasien Pediatrik Rawat Inap di RSUP H. Adam Malik Medan Periode Januari-Juni 2012, Skripsi, Universitas Sumatera Utara, Medan.
Bolhuis,M.S., Prashant N. Panday, Arianna D. P, Jos G. W. Kosterink and Alffenaar J.W., 2011, Pharmacokinetic Drug Interactions of Antimicrobial Drugs: A Systematic Review on Oxazolidinones, Rifamycines, Macrolides, Fluoroquinolones, and Beta-Lactam. Pharmaceutics, 3, 865-913. doi:10.3390/pharmaceutics3040865
Published
2022-04-30
Section
Articles
