Correlation of Interleukin-6 And Hs-Crp Value in Covid 19 Patients With Severe Symptoms in Makassar Prodia Clinical Laboratory

Mirnawati Mirnawati; Dewi Saroh

doi:10.31001/biomedika.v15i2.1650

Abstract

Corona Virus Disease 2019 (COVID-19) is a new infectious disease caused by a novel coronavirus known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2).Patients with severe symptoms of Coronavirus disease-19 (Covid-19) experience hyperinflammation and also a cytokine storm which contributes to the high mortality rate. A useful clinical parameter is needed for risk stratification of Covid-19 patients. This study aims to determine the relationship between Interleukin-6 and Hs-CRP values in Covid-19 patients with severe symptoms at the Prodia Makassar Clinical Laboratory. This research is an observational analytic study with a cross sectional approach. The subjects of this study were 30 patients with Covid-19 with severe symptoms, the time of the study was December 2021 - April 2022. Interleukin-6 and Hs-CRP examinations were carried out on the Roche Cobas 6000 automatic device. Analysis of the data using the Pearson-Product Moment Correlation Test using the help of the Statistical Product and Service Solution program. The results of the research analysis showed a significance value of 0.000 < 0.005. The conclusion of this study is that there is a relationship between Interleukin-6 and Hs-CRP in Covid-19 patients with severe symptoms at the Prodia Makassar Clinical Laboratory. The relationship between the two variables is strong and positive so that as HS-CRP increases, IL-6 will also increase.

Keywords: interleukin-6, hs-crp, COVID-19, severe symptoms, patient

References

Agustin, M. 2016. Gambaran C-Reaktice Protein Pada Obesitas. Politeknik Kesehatan Bandung Jurusan Analis Kesehatan.
Anisa, N., A., 2016. Kadar C-Reaktive Protein (CRP) Pada Remaja Putri Stunted Obesity Di Pedesaan Jepara. Journal Of Nutrition College. Vol. 5, No. 2, 72.
Cruz, A.S., Frias, A.M., Oliveira, A.I., dias, L., Matos, A.R., Carvalho A, et al. 2020. Interleukin-6 is a biomarker for the development of fatal severe acute respiratory syndrome coronavirus-2 Pneumonia. Journal Original research Immunology. Frontiers. P.1-10.
Gubernatorova, E.O., Gorshkova, E.A., Polinova, A.I., Drutskaya, M.S. 2020. IL-6: Relevance for immunopathology of SARS-CoV-2. Journal Cytokine and Growth Factor Reviews. Elsevier. Vol. 53. P. 13-24
Kerboua, K.E. 2021. NLR: A cost-eveffective nomogram to guide therapeutic in Covid-19. Journal Immunological Investigation Elsevier. p.1-9.
Kerget B, Kerget F, Kocak AO, Kiziltunc A, Araz O.,et al, 2020. Are serum interleukin-6 and surfactan Protein D Levels Associated with the Clinical Course of COVID-19. In Covid-19 Pulmonary Disease And Biomarkers. Lung 198 P. 777-784
Kim, S.J., Lee, J.Y., Yang, J.W., Lee, K.H., Effenberger, M., Szpirt, W. et al. 2021, Immunopathogenesis and treatment of cytokine storm in COVID-19. In Journal Theranostics. Vol. 11. p. 316-327.
Liu, H., Chen, S., Liu, M., Nie, H., Lu, H. 2020c. Comorbid Chronic Diseases are Strongly Correlated with Disease Severity among COVID-19 Patients: A Systematic review and Meta-Analysis. Review In Journal Aging and Disease. Vol. 11(3). P. 668-678.
Liu, J,. Liu, Y., Xiang P., Pu, L., Xiong, H., Li, C. et al. 2020b. Neutrophyl-to- lymphocyte ratio predicts critical illness with 2019 coronavirus disease in the early stage. Journal of Translational Medicine, BMC. P. 1-12.
Mojtabavi, H., Saghazadeh, A., Rezaei, N. 2020. Interleukin-6 and severe Covid-19: A Systematic review and meta analysis. In Short Review in Journal Eur. Cyokine Netw. Vol. 31(2). P.44-49
Sayah W, Berkane I, Guermache I, Sabri M, Lakhal FZ, Rahali SY et al., 2021, Interleukin-6, procalcitonin and neutrophil-to-lymphocyte ratio: Potential immune-inflamatory parameters to identify severe and fatal forms of COVID-19. In Journal Cytokine. volume (141), ELSEVIER, P.1-8
Sharifpour M, Rangaraju S, Liu M, Alabyad D, Nahab FB, Creel-Bulos CM, et al. 2020. COVID-19 Quality & Clinical Research Collaborative. C-Reactive protein as a prognostic indicator in hospitalized patients with COVID-19. Journal PLoS One. Volume 15(11):e0242400.
Shi S, Liu X, Xiao J, Wang H, Chen L, Li J et al.,2020. Prediction of adverse clinical outcomes in patients with coronavirus disesae 2019. In Research Article, WILEY, P. 1-9

Stringer D, Braude P, Myint PK, Evans L, Collins JT, Verduri A, et al. 2021. The role of C-reactive protein as a prognostic marker in COVID-19. Int Journal Epidemiol. Volume 50(2). P 420-429.
WHO. 2020. Coronavirus disease COVID-19 situation reports.
Wibisana, G. A., Putu, N., Widhiani, V., Syifa, R. R. D. M., Warnaini, C., Studi, P., Dokter, P., Kedokteran, F., Mataram, U., Ilmu, D., Masyarakat, K., Kedokteran, F., Mataram, U., Risiko, F., & Klinis, M. (2021). Faktor – faktor Terkait Tingkat Keparahan Infeksi Coronavirus Disease 2019 ( COVID-19 ): Factors Related To The Severity Of Coronavirus Disease 2019 ( COVIS-19 ) Infection : A Literature Review. 9, 48–55.