Analysis of Interleukin-17 Levels in Patients with Thrombocytopenia

  • Lidwina Septie Christyawardani Department of Biomedical Science, Clinical Chemistry, Post-graduate Program of Universitas Hasanuddin, Makassar, Indonesia
  • Mansyur Arief Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
  • Uleng Bahrun Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia

Abstract

Thrombocytopenia or platelet deficiency is a condition, in which platelet level in the blood circulation is below normal, which is less than 150,000 cells/µl. Thrombocytopenia is classified into some conditions, including decreased platelet production, increased need for platelets, and other thrombocytopenia. The need for increased platelets can be subdivided into primary immune thrombocytopenia, secondary immune thrombocytopenia, non-primary ITP, and thrombocytopenia that are not immune-mediated. Several cytokines play a role in the process of thrombocytopenia, one of which is Interleukin-17 (IL-17) that will be further discussed in this study. A previous study reported that IL-17 production increased in ITP and cITP patients. The objective of this study was to analyze the IL-17 levels and figure out the differences in IL-17 levels in the serums of patients with primary ITP and secondary ITP. The samples were taken from Wahidin Sudirohusodo Hospital and the specimens were examined in the Research Unit Laboratory of the Faculty of Medicine, Universitas Hasanuddin/Hospital of Universitas Hasanuddin. The comparative test resulted in p-value = 0.005, where p <α = 0.05; and therefore, there was a significant difference between IL 17 levels in ITP and non-primary ITP.

Keywords: thrombocytopenia, ITP, interleukin-17

References

Abbas, A. K., Lichtman, A. H., & Pillai, S. (2015). Imunologia Celular e Molecular - Abbas 8ed-2. Elsevier Editora Ltda.
Aboud, N., Depré, F., & Salama, A. (2017). Is Autoimmune Thrombocytopenia Itself the Primary Disease in the Presence of Second Diseases? Data from a Long-Term Observation. Transfusion Medicine and Hemotherapy. https://doi.org/10.1159/000449038
Ayesh, M. H., Alawneh, K., Khassawneh, B., Khader, Y., & Kasasbeh, A. (2013). Adult primary and secondary immune thrombocytopenic purpura: A comparative analysis of characteristics and clinical course. Clinical and Applied Thrombosis/Hemostasis. https://doi.org/10.1177/1076029611433641
Das, S., & Khader, S. (2017). Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved]. F1000Research. https://doi.org/10.12688/f1000research.10862.1
Guyton and Hall. (2014). Guyton dan Hall Buku Ajar Fisiologi Kedokteran. In Elsevier, Singapore. https://doi.org/10.1016/B978-1-4160-5452-8.00020-2
Jin, W., & Dong, C. (2013). IL-17 cytokines in immunity and inflammation. Emerging Microbes and Infections. https://doi.org/10.1038/emi.2013.58
Kosasih, E.N. Kosasih dan A.S. 2008. Tafsiran Hasil Pemeriksaan Laboratorium Klinik. KARISMA Publishing Group: Tangerang
lefever Joyce. (2008). Pedoman Pemeriksaan Laboratorium Dan Diagnostik. Buku Kedokteran EGC. https://doi.org/10.17576/jsm-2018-4701-05
Li, Q., Zhang, L., Xia, R., Zeng, Q., Wang, Y., Xia, L., … Yang, M. (2015). Plasma Levels of Interleukin 12 Family Cytokines and Their Relevant Cytokines in Adult Patients with Chronic Immune Thrombocytopenia before and after High-Dose Dexamethasome Treatment. Medical Principles and Practice. https://doi.org/10.1159/000433472
Liang, Y., & Gibson, J. (2017). Location or Hukou: What most limits fertility of Urban women in China? Asia and the Pacific Policy Studies. https://doi.org/10.1002/app5.188
Makis, A., Gkoutsias, A., Palianopoulos, T., Pappa, E., Papapetrou, E., Tsaousi, C., … Chaliasos, N. (2017). Prognostic Factors for Immune Thrombocytopenia Outcome in Greek Children: A Retrospective Single-Centered Analysis. Advances in Hematology. https://doi.org/10.1155/2017/7878605
Matzdorff, A., Meyer, O., Ostermann, H., Kiefel, V., Eberl, W., Kühne, T., … Rummel, M. (2018). Immune Thrombocytopenia - Current Diagnostics and Therapy: Recommendations of a Joint Working Group of DGHO, ÖGHO, SGH, GPOH, and DGTI. Oncology Research and Treatment. https://doi.org/10.1159/000492187
Moulis, G., Palmaro, A., Montastruc, J. L., Godeau, B., Lapeyre-Mestre, M., & Sailler, L. (2014). Epidemiology of incident immune thrombocytopenia: A nationwide population-based study in France. Blood. https://doi.org/10.1182/blood-2014-05-578336
Sari, Teny Tjitra. 2018. Immune Thrombocytopenic Purpura. Sari Pediatri, Vol. 20, No. 1, Juni 2018
Sultan, S., Ahmed, S. I., Murad, S., & Irfan, S. M. (2016). Primary versus secondary immune thrombocytopenia in adults; a comparative analysis of clinical and laboratory attributes in newly diagnosed patients in Southern Pakistan. Medical Journal of Malaysia.
Ye, Xin et al. 2015. The Role of IL-23/Th17 Pathway in Patients with Primary Immune Thrombocytopenia. PLOS ONE DOI:10.1371/journal.pone.0117704 January 26, 2015
Zufferey, A., Kapur, R., & Semple, J. (2017). Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP). Journal of Clinical Medicine. https://doi.org/10.3390/jcm6020016
Published
2020-07-22